Because of the severity of the growth defects in different sensor deletion mutants, Wsc1 and Mid2 have been suggested to contribute to the bulk of CWI signaling, with partially overlapping functions 13 , Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1. Trends Microbiol 11 — Although the size and stability of the Wsc1 patches are also reminiscent of yeast eisosomes 30 , they do not colocalize our unpublished results. Clearly, any agent that interferes with proper cell wall synthesis will result in cell lysis and death. Architecture and biosynthesis of the Saccharomyces cerevisiae cell wall. A set of five membrane-spanning sensors Wsc1 to Wsc3, Mid2, and Mtl1 detect cell surface stress and commence the signaling pathway upon perturbations of either the cell wall structure or the plasma membrane. In fact, mutants defective in O-mannosylation have been shown to have cell lysis defects As stated above, we also suggest that the double-anchored polypeptide chain of Wsc1 forms a crucial part of a sensor by which mechanical stress at the cell surface is detected by stretching of the nanospring.
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